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The former generally refers to the biphasic dose-response effects of single, often isolated, bioactive compounds (hormetins), such as resveratrol or curcumin
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Studies have postulated that the cause may be ascribed to the reduction in the excitability of pain transmitting dorsal horn neurons via hyperpolarization due to MT1/2-melatonin binding 89
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J Biol Chem 277:2694426949 Couturier J, Przybyla-Toscano J, Roret T, Didierjean C, Rouhier N (2015) The roles of glutaredoxins ligating Fe-S clusters: sensing, transfer or repair functions
