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Then, the media was removed, washed with 1X PBS, and stained with a 1:1 mixture of AO and EtBr (100 g/mL each) for 30 min

Moreover, mP-NPs-DNase/PTX nanoparticles consisting of a paclitaxel (PTX) prodrug nanoparticle core and a poly-l-lysine (PLL) conjugated with the matrix metalloproteinase 9 (MMP-9)-cleavable Tat-peptide-coupled deoxyribonuclease I (DNase I) shell can inhibit malignant tumor growth and distant metastasis by releasing DNase I responsive MMP-9 and further degrading the structure of tumor associated neutrophil extracellular traps after accumulation at the tumor site (113)

The progression of diabetes and, consequently, prolonged exposure to this condition, favor the development of secondary complications of DM

Treatment side-effects include elevated aminotransferase levels and injection site reactions (lipohypertrophy)

DeepMet also identified a series of putatively novel metabolites that were revealed after careful review of the literature to be known metabolites that were missing from the HMDB (and, in some cases, even PubChem) 27,29,45,46,47,48,49,50,51,52 (Extended Data Fig