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But when the same receptor gets hit with the same signal nonstop, a chain of events unfolds: The cell marks the receptor with a chemical tag (phosphorylation) A protein called beta-arrestin grabs the tagged receptor and shuts down further signaling The cell pulls the receptor inside (internalization) Some receptors get recycled and put back on the surface

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10.1155/2022/3744618 108 NontprasertA.Nosten-BertrandM.PukrittayakameeS.VanijanontaS.AngusB

We next analysed the phosphorylation status of T405 and S267 in response to external stimuli such as epidermal growth factor (EGF) or phorbol 12-myristate 13-acetate (PMA)