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Description
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After four weeks, the diameter of micro vessels at the fingertips and thus microcirculation was significantly increased in 53.8% of the patients supplemented with Pycnogenol compared to 32% of subjects of the placebo group (31)

Levels are roughly 200 ng/mL around age 20 and fall to about 80 ng/mL by age 60

Biotin requirements are slightly higher in pregnancy (30 g/day is the recommended intake for pregnant women)

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Therapeutic targets in age-related macular disease
