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Six new ligands of the Tri-Click (TC) class were prepared and their ability to coordinate three copper(II) ions was determined using electrospray ionisation-mass spectrometry (ESI-MS)

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In comparison to younger individuals, the elderly take about three times more medications and usually, they follow multi-drug treatments (polypharmacy) (153155), a condition that constitutes a major challenge for health professionals and patients, who often experience memory impairment and either forget to take their medication or take it multiple times (156)

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Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress