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Therapeutic approaches that target chronic hypoxia in CKD HIF stabilizers Oxygen-dependent prolyl-hydroxylases (PHDs) are key regulators of HIF-dependent erythropoiesis, providing an essential theoretical basis for applying HIF-PHD inhibitors (HIF-PHIs) to treat renal anaemia

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Cureus, 11 , e4591

BPC-157 maintained its effect even under nitric oxide synthase blockade, supporting its modulation of central dopaminergic and serotonergic signaling