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Triple Receptor Agonism The defining characteristic of retatrutide is its simultaneous activation of three key metabolic hormone receptors: GLP-1 Receptor: Activation increases insulin secretion in a glucose-dependent manner, reduces glucagon secretion, delays gastric emptying, and decreases appetite through central nervous system effects GIP Receptor: Stimulates insulin secretion and enhances the body's response to glucose while potentially improving lipid metabolism Glucagon Receptor: Activation increases energy expenditure and lipid oxidation, which complements the anorectic effects of GLP-1 receptor activation This triple agonism approach is designed to address multiple aspects of metabolic dysfunction simultaneously, potentially offering superior efficacy compared to single or dual receptor agonists[1][2]

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A competitive GST P1-1 assay was performed to identify the inhibition type of these five compounds