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Mainly through these mechanisms (27), Pycnogenol supplementation has been shown in RDP human clinical trials to beneficially affect cardiovascular health (9, 11, 12, 2022, 2831), chronic venous insufficiency (32, 33), cognition (13, 14, 3439), joint health (4042), skin health (43, 44), eye health (45, 46), womens health (12, 47, 48), respiratory health and allergies (4951), oral health (52) and sports performance (5356) (Figure 2)

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Coffee polyphenols prevent cognitive dysfunction and suppress amyloid beta plaques in APP/PS2 transgenic mouse

Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes

Notably, pathways such as the mTORAMPK, TFEBCLEAR, and p62Keap1Nrf2 axes act as central nodes that integrate upstream environmental and intracellular cues into coherent autophagic responses