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Sensory testing may improve, and patients often report regaining sensation in their feet

In line with the energy starvation hypothesis [30], which induced that energy supply scarcity was responsible for the contractile dysfunction in heart failure

S-Adenosylmetliionine and methylation

This transmembrane protein facilitates the uptake and intracellular trafficking of free fatty acids, as well as esterification into triglycerides in heart and skeletal muscle cells [2, 18, 38, 39]

Coenzyme Q10 (CoQ10) and L-carnitine are naturally occurring compounds that play essential roles in cellular energy production

Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, Didonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL