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Hepatic 25-hydroxylation via cytochrome P450 isoform CYP2R1 converts cholecalciferol to 25(OH)D, followed by renal 1-hydroxylation through CYP27B1 to yield bioactive 1,25(OH)2D [153]

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J Physiol 571(1):147163 Saleem S, Ahmad AS, Maruyama T, Narumiya S, Dor S (2009) PGF 2 FP receptor contributes to brain damage following transient focal brain ischemia

This heterogeneity underscores the uneven trajectory of peptide therapeutics within musculoskeletal medicine

TRPM2 channel in transfected cell lines is gated by extracellular and intracellular ROS, possibly by interacting with the ADP ribose pyrophosphatase enzyme in the tail of the protein C domain (Perraud et al., 2001