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IGF-1 LR3 signals through IGF-1R for systemic anabolic effects while PEG-MGF's E-domain activates satellite cells through a distinct receptor, making them complementary tools for dissecting local vs systemic muscle growth signaling

Similarly, cannabidiol (CBD), which also directly influences endocannabinoid transmission, diminishes ROS accumulation, activates the Nrf2 pathway through NF-kB inhibition and downregulates oxidative enzymes [124, 125]

10.3892/ijmm.2019.4244 45 LiuY.TavanaO.GuW

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