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Only then could the researchers clearly distinguish identity based on spatial locations, and differential expression of zonation markers was observable

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Multiple bioinformatic approaches revealed that high expression of five genes ( ZnT1 , 5-7 , and 9 ) was significantly correlated with better overall survival (OS), first progression survival (FPS), and post-progression survival (PPS), while upregulated ZnT2-4 , 8 , and 10 expressions was markedly associated with poor OS, FP, and PPS

In addition to the high content of readily oxidizable molecules like catecholamines, and polyunsaturated fatty acids, and relatively lower antioxidant levels compared to other organs, these factors make the brain more vulnerable to oxidative stress