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It has also been observed that VIC exhibits antimicrobial properties, inhibiting the growth of several pathogens, such as Pseudomonas aeruginosa , Staphylococcus aureus , and Escherichia coli , and at high concentrations, can also inhibit biofilm formation

Hepatotoxicity, resulting from various causes, remains a key factor for removing drugs from pharmaceutical research and clinical usage 25 2.1

Kiriyama S, Takada T, Strasberg SM, Solomkin JS, Mayumi T, Pitt HA, Gouma DJ, Garden OJ, Buchler MW, Yokoe M, Kimura Y, Tsuyuguchi T, Itoi T, Yoshida M, Miura F, Yamashita Y, Okamoto K, Gabata T, Hata J, Higuchi R, Windsor JA, Bornman PC, Fan ST, Singh H, de Santibanes E, Gomi H, Kusachi S, Murata A, Chen XP, Jagannath P, Lee S, Padbury R, Chen MF, Tokyo Guidelines Revision C (2012) New diagnostic criteria and severity assessment of acute cholangitis in revised Tokyo Guidelines

The issue is further complicated by other gut abnormalities, such as small intestinal bacterial overgrowth (SIBO) and an altered gut microbiota, which occur in PD with variable frequency