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This action is presumed to subsequently elevate levels of insulin-like growth factor-1 (IGF-1), recognized as the primary mediator of the anabolic properties of growth hormone

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Neale EP, Batterham MJ, Tapsell LC (2016)

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27,28 Notably, impairment of the unfolded protein response (UPR), including XBP1 or IRE1 deficiency, has also been implicated in -cell transdifferentiation or dedifferentiation
