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Moreover, the rapid conversion of glutamate to glutamine in astrocytes ensures a low level of intracellular glutamate, which creates a low threshold across the astrocyte plasma membrane that stimulates glutamate uptake, while neurons maintain a high level of intracellular glutamate, which decreases their ability to uptake glutamate [78,79,80,81,82,83]

116 They may also be a therapeutic target for COPD