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PI/Ca : Experimental studies have shown that increased cAMP and PKA activation inhibits methacholine- and histamine-induced phosphoinositide (PI) hydrolysis and its effect to cause Ca2+ mobilization (Hoiting et al, 1996

Several observations point toward dHTC3 functioning as a molecular glue, most notably the lack of an apparent hook effect by dHTC3 and the inability of epi -dHTC3 to block its activity, as well as its unexpected selectivity for BD1 over BD2

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