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4C, with the cell nucleus stained by DAPI (blue), a greater intensity of red DOX fluorescence signals was observed in OCM-1 cells compared to ARPE-19 cells, indicating a higher uptake of nanocomposites by OCM-1 cells

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Characterization- and formulation-associated issues include the correlation of in vitro model with in vivo studies, the usage of a high amount of surfactant, the precipitation of drug in vivo, the oxidation potential of lipid components, the difficulty of low encapsulation, etc

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