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Briefly, Caco-2 cells were seeded in 96-well plates and allowed to grow in culture media for three weeks, feeding at 2-day intervals

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes

When B12 pathways are disrupted by chronic illness, the methylation cycle stalls, leading to a dangerous accumulation of homocysteine in the bloodstream
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Corley, co-authors of the study were Jameson R

Gastrointestinal: Nausea, stomach discomfort, bloating, or dyspepsia