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Introduction The prevalence of allergic diseases has dramatically increased worldwide, especially in industrialized countries, for unknown reasons ( DEHP, a widespread environmental contaminant and endocrine disruptor, is used principally as a plasticizer for a wide range of purposes, in both developed and developing countries ( in vitro ( Dendritic cells (DCs) are the key innate cell type that link innate and adaptive immunity, and DC dysregulation promotes the development of allergic diseases, as DCs instruct the differentiation of allergen-specific T helper 2 (Th2) cells, and in turn, lead to lung inflammation and remodeling ( + cDC is the major interleukin (IL)-12-producing cDC subset, and blocking the differentiation of this subset skews immunity to the Th2 response ( + cDCs ( + T-cell anergy ( To address these important issues, we explored the potential pathogenic role of DEHP in the development of allergic asthma and its underlying mechanism