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The study on the brains of the Mecp2-308 mouse model of ASD has shown a reduced ATP production accompanied by a significant reduction in complexes I, II, and V activities in the cerebellum and striatum of the mutant mice [78]

Increased L-carnitine reversed the oxidative stress.[ref] Psychosocial stress would include things like stress from relationships, work, and finances

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Balancing the ratio allows the activity of the enzyme pyruvate dehydrogenase to be maintained because acetyl-CoA production will match acetyl-CoA entrance into the TCA cycle, allowing more pyruvate to be shuttled into the mitochondria without being reduced to lactate (30, 31)

A., & Greenhaff, P