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*Correspondence: Herbert Renz-Polster, [email protected] This article was submitted to Non-Neuronal Cells, a section of the journal Frontiers in Cellular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

BBB dysfunction is associated with long COVID-induced cognitive impairment Given the significantly increased serum concentrations of S100, our data indicated that active and acute SARS-CoV-2 infection is associated with potential BBB dysfunction in individuals with neurological impairment

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Therefore, by activating this NCOA4-mediated ferritinophagy pathway, Erastin promotes the release of free iron, which in turn amplifies ROS production and lipid peroxidation, resulting in an autophagy-dependent mode of ferroptosis