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Research has demonstrated that BMAL1 and CLOCK can modulate the transcriptional activity of NF-B, thereby playing a significant role in immune responses (Spengler et al., 2012)

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While widely used and effective, it can cause thermal damage to adjacent tissues due to less precise heat control, leading to higher rates of AEs

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doi: 10.1016/S0002-9440(10)64857-2 [DOI] [PMC free article] [PubMed] [Google Scholar] 21.Park J.M., Cho J.K., Mok J.Y., Jeon I.H., Kim H.S., Kang H.J., Jang S