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A representative study of community-dwelling elderly found that higher glutathione levels were associated with higher levels of physical health, fewer illnesses, and higher levels of self-rated health.15 As might be expected, then, GSH status has been found to parallel telomerase activity, an important indicator of lifespan.16 This depletion of GSH also shows up as progressive loss of mitochondrial function due to accumulation of damage to mtDNA.17 The ability of animal species to protect their mtDNA is directly proportional to longevity.18 GGT as Measure of Glutathione Need GGT (gamma-glutamyl transferase) is upregulated in proportion to the need for glutathione such as for the detoxification of POPs.19 It provides the rate-limiting cysteine through a catabolic salvage pathway. Increases in GGT correlate with many diseases: metabolic syndrome, both fatal and nonfatal coronary heart disease (CHD) events, atherosclerosis, fatty liver, diabetes, cancer, hypertension, and carotid intima-media thickness.2022 Of particular note, these are elevations of GGT within the supposedly normal range

& Mare, A

Nucleic Acids Res 38:72487259 Wang HJ, Deng J, Wang JY, Zhang PJ, Xin Z, Xiao K, Feng D, Jia YH, Liu YN, Xie LX (2014) Serum miR-122 levels are related to coagulation disorders in sepsis patients

These studies underscore the essential role of GSH in normal functioning of the liver

doi:10.1109/TBME.2013.2243912 92

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