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In an open-label uncontrolled clinical trial in 13 subjects with RLS, six participants had a 50% or greater reduction in symptom scores after eight weeks of treatment with dipyridamole and four participants experienced a smaller degree of improvement (Garcia-Borreguero 2018)

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451 In streptozotocin (STZ)-induced diabetic rat and mouse models, elevated expression of P2X2 and P2X3 receptors in the DRG, along with increased current density and P2X4 receptor expression on satellite glial cells, indicates that P2X4 receptor activation in the DRG significantly contributes to DPN-induced mechanical pain hypersensitivity (Fig