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One patient with the combination of del(17p) and chromosome 12 trisomy had an abnormally high level of mitochondrial superoxide after AZD-5991 and ibrutinib treatment (a 551-fold increase while on ibrutinib alone and a 74-fold increase while on combination treatment with ibrutinib and CB-839

Some additional folate is useful at this time though, from diet or from supplements (preferably folinic or methylfolate), the right amount can be individual, from 200-800mcg

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Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia