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(110) showed that endogenously generated NO and ROS contribute to HIF-1 accumulation by inhibiting prolyl hydroxylase domain proteins (PHDs) via S-nitrosation of PHD2, thus preventing HIF-1 degradation during hypoxia (110)
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Tears cause pain with gripping, twisting, and weight-bearing through the wrist
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Zhu J, Zhou D, Yu M, Li Y
In addition to its capacity for direct transcriptional regulation, MYC may orchestrate tumorspecific metabolic reprogramming through indirect, RNAdependent means (i.e., through miRNAs and the regulation of RNA processing enzymes such as HNRNPA1)
