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In combination, the addition of IL-6 appears to counteract the changes to neural function induced by low concentrations of TNF-, while at high concentrations of TNF- the addition of IL-6 had little to no effect

However, significant inactivation was detected at the lowest treatment time when the PEF treatments were applied at the two higher electric field strengths assayed (15 and 20 kV/cm)

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However, careful consideration is warranted when employing GPX4 inhibitors and ferroptosis inducers in AML and other cancer types, as the tumor microenvironment significantly influences tumor progression, either by promoting or inhibiting it

Catalase and GPx facilitate the reduction of H 2 O 2 to H 2 O (Bizon et al

doi: 10.1084/jem.20041257 29 McGeachyMJChenYTatoCMLaurenceAJoyce-ShaikhBBlumenscheinWMet al