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Newbold, a NYC psychiatrist, that demonstrated neuropsychiatric benefits at high doses (60 mg per day SQ/IM) over a six-month period

In vivo study showed that UA can induce autophagy, the primary process for clearing intraneuronal aggregated -synuclein, by inhibiting mTOR/ULK1 signaling in the midbrain of SNCA A53T transgenic mice

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The oxidative stress in the CNS is associated to many neurodegenerative diseases

[21] When treated with cyanocobalamin, patients with Leber's disease may develop serious optic atrophy, possibly leading to blindness, based on few case reports