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The autism group had lower levels of biotin than did the neurotypical group (-20%, p = 0.001) at the start of the study, and the supplement significantly increased levels of biotin (+51%, p = 0.008) in the treatment group

Lipolytic actions of leptin are dependent on the leptin receptor, since obese fa/fa Zucker rats (112) and db/db mice (32) that have an inactivating mutation of the long form of the leptin receptor are resistant to leptin-induced lipolysis

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