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The succinimide of dHTC1 makes hydrogen-bonding interactions with the side chain of H378, backbone carbonyl of H378, and backbone nitrogen of W380, which are all similar to the contacts made by the glutarimide of lenalidomide 54
Patients were supplemented with either 10 g of ascorbate or placebo

[DOI] [PMC free article] [PubMed] [Google Scholar] 141.Field L.S., Luk E., Culotta V.C

It is difficult to find a study that indicates vitamin C was not beneficial in some way

Glutathionylated proteins occur mainly in intracellular space because GSH is located in the cytoplasm and Cys residues of proteins are in a reduced form and able to form mixed disulfides
