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Compared to the placebo group, those who received the silymarin saw a "significant decrease" in their levels of key diabetic markers hemoglobin A1C, fasting blood sugar, total cholesterol, low-density lipoprotein ("bad") cholesterol, and triglycerides.17 The second is a recent review published in the Annals of Hepatology in 2021, much of which relates to silymarin's effect on insulin resistance,18 a prominent marker for type 2 diabetes.19 Two of the studies referenced in the review were animal studies that administered 26.25-100mg/kg of silybin to rat subjects (equivalent to around 366-1,395mg for an 86kg, or 190lb, human) across 6-12 weeks

[DOI] [PubMed] [Google Scholar] 96.Grabarevic Z., Tisljar M., Artukovic B., Bratulic M., Dzaja P., Seiwerth S., Sikiric P., Peric J., Geres D., Kos J
Allergy avoidance: Removal of excipients, dyes, or allergens

While it is often the drug of choice for fever in children, use for fever in the first year of life has been associated with an increase in asthma and other allergic symptoms later in childhood
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