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A critical question in understanding these conditions is how the observed metabolite differences in ME/CFS, Fibromyalgia, and GWS compare with those seen in other diseases associated with chronic fatigue or cognitive decline

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Mol Cell Biochem (2013) 381(12):12737

Breintoft K, Pinnerup R, Henriksen TB, Rytter D, Uldbjerg N, Forman A, et al

Identification of a variant antioxidant response element in the promoter of the human glutamate-cysteine ligase modifier subunit gene

Therefore, this review aims to provide a timely update on the sources of ROS in different types of exercise, as well as the paradoxical role of ROS in acute and chronic exercise