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Malonyl-CoA generated by acetyl-CoA carboxylase - isoform 2 (ACC2) binds with high affinity to each of the CPTI isoforms and acts like a switch to control the sensitivity to this key inhibitory molecule and regulate the transfer of fatty acids into the mitochondrial matrix and thence their oxidation

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doi: 10.3389/fbioe.2020.00495 190 GopalTKumarNPerriotte-OlsonCCaseyCADonohueTMHarrisENet al

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BCSO exerts these effects via downregulating the expression of TLR4 and key inflammatory mediators such as IL-1, IL-6, TNF-, and HMOX1 on a genetic and protein level and upregulation of GSH protein

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