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As we age, more cells become senescent, meaning they can no longer divide or support their tissues

Nat Genet 2009

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Extracellular lactate has been shown to be the major carbon source feeding the tricarboxylic acid (TCA) cycle within multiple different tissues, indeed in all tissues except the brain

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Ma C, Liu Y, He S et al (2020) Association between leukocyte mitochondrial DNA copy number and non-alcoholic fatty liver disease in a chinese population is mediated by 8-Oxo-2-deoxyguanosine