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Increasing dietary calcium feedback inhibits the secretion of parathyroid hormone (PTH) and, subsequently, the activation of 25 hydroxycholecalciferol to 1,25 dihydroxycalciferol (vitamin D 3

Folate deficiency may result in moderately low total serum vitamin B12 concentrations because both folate as a cosubstrate (methyl donor) and vitamin B12 (as a coenzyme) are required in the remethylation metabolic pathway of homocysteine (see Figure 22b.2) (Klee, 2000)

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While increased muscle mass may be desirable in some contexts, it can complicate research focused purely on fat loss and metabolic effects

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When metabolism slows, the body tends to use fewer calories, and fat reduction becomes more challenging