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4.2.1 Immune checkpoint inhibitor (ICI) therapies in HCC In recent years, ICI therapies have been well recognized as a main component in systemic first-line treatment of HCC due to considerably less systemic side effects and more durable responses compared with other conventional therapies (He and Xu, 2020)

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GSH delivery could be improved by some derivatives with hydrophobic chains of different length or by I-152, which is a conjugate of NAC and s-acetyl--mercaptoethylamine (MEA), which is able to release NAC and MEA and increase GSH content [100]

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