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Acknowledgements The authors express gratitude for the financial support provided by the Iran National Science Foundation (INSF) under project No.4004509, the Biotechnology Development Council of the Islamic Republic of Iran under grant No

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However, resistance to EGFR inhibitors frequently emerges through activation of alternative signaling pathways or secondary mutations, often accompanied by metabolic adaptation including increased OXPHOS dependency or enhanced autophagy [57,58,59,60,61]

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