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Angiogenesis cuts both ways: The pro-angiogenic, pro-migration mechanisms that make these peptides interesting for repair are the same processes that are undesirable in the presence of malignancy an unresolved theoretical concern and a genuine reason for caution
Proton pump inhibitors (ppis): these medications used to treat gastroesophageal reflux disease (gerd) can decrease the absorption of vitamin b12, increasing the risk of deficiency

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And theres no requirement that manufacturers ensure that products are free of contaminants

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