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Furthermore, bridging the translational divide requires embedding mechanistic investigations (eg, biomarker analyses, advanced imaging to assess vascular remodeling) within clinical trials to validate whether mechanisms identified preclinically hold true in humans and provide a biological rationale for observed clinical effects

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The National Cholesterol Education Programs Adult Treatment Panel III (ATP III) identified six components of the MetS: abdominal obesity, insulin resistance with or without glucose intolerance, atherogenic dyslipidaemia, raised blood pressure, prothrombotic state, and proinflammatory state [2]

Goal-Specific Dosing Considerations The optimal MOTS-c dose is not one-size-fits-all: it shifts depending on whether the clinical goal is metabolic correction, athletic performance enhancement, or anti-aging and longevity support