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These findings highlight CTP's potential as a functional food component that supports cardiovascular resilience, particularly in individuals at elevated risk of atherosclerosis [179, 183-185]

Chronic stress has been associated with releasing stress hormones such as cortisol, contributing to oxidative stress and inflammation

In addition, the glutamine transaminases coupled to -amidase may provide anaplerotic -ketoglutarate as an energy source in rapidly dividing cells (Cooper et al., 2016)

Possible causative mechanisms of CNS inflammation and neuroglial reactivity include direct effects through injury or infection of the brain, reactivation of endogenous microbial reservoirs in CNS cells, autoimmune reactivity with specific neural, glial, or immune system targets, repetitive mechanical strain, cerebrovascular hypertension, cerebral hypoperfusion and/or ischemia, recognition of danger-associated molecular patterns (DAMP), vagal dysfunction, norepinephrine or angiotensin II overload, or, generally, exposure to chronic stress (VanElzakker, 2013

10.1016/j.ijrobp.2023.04.004 182 XiangP.ChenQ.ChenL.LeiJ.YuanZ.HuH.et al (2023)