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doi: 10.1073/pnas.95.26.15592
doi: 10.1002/jcp.28347
65 In a trial of 55 patients with impaired glucose tolerance (or T2DM), pioglitazone administered with a hypocaloric diet improved steatosis and inflammation but not fibrosis
When taken in doses of 0.5-2 grams a day there may be minimal side effects
Furthermore, this process inhibits the expression of lipogenesis-related genes, ultimately enhancing ketogenesis (27, 28)
Before taking it, discuss the risks and benefits with your doctor
