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Research suggests that under conditions of metabolic stress (such as overeating or oxidative stress), MOTS-c translocates from the mitochondria to the cell nucleus in an AMPK-dependent manner

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Pregnancy and lactation are anabolic states that are orchestrated via hormonal and metabolic changes that redirect nutrients to specialized maternal tissues characteristic of reproduction, such as the placenta and mammary glands and, in turn, the developing fetus or infant, respectively (219)