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PET tracers showed that cancer cells rely heavily on glutamine uptake via mTORC1 signaling, while myeloid cells in the TME are more dependent on glucose, as are T cells and cancer cells (but to a lesser extent) 128

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References Adibi SA, Baraona E, Lieber CS

(25) It was intended to clarify the need for selectivity in the clinic, but since toxicological studies did not reveal any major difference between cagrilintide 23 and NN1213, the development of NN1213 is currently on hold