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In studies investigating the extension of gestational weeks in pregnant females with early-onset preeclampsia treated with metformin, metformin (1,0003,000 mg/d) significantly prolonged the expected time for treatment, and shortened the length of stay in the neonatal intensive care unit

The reactive cysteine thiol group donates electrons to stabilize oxidative species

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The lubricating layer (PP), containing phosphatidylserine (PS), reduces frictional stress, while the regenerative layer (GM/GV), composed of gelatin methacrylate (GM) and vanillin-modified gelatin (GV), scavenges ROS and mitigates AGEs-induced collagen disorder deposition

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Its semi-open left-handed core domain comprises four pairs of antiparallel amphipathic -helices