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Despite their great potential, their clinical translation is often hindered by poor bioavailability and stability, rapid clearance and short half-life, low membrane permeability, which hinders their ability to cross cellular barriers and reach their intended targets, immunogenicity, and challenges regarding patentability and intellectual property protection

Tumor derived lactate accumulation via aerobic glycolysis leads to an acidified TME

MZ: Conceptualization, Resources, Visualization, Writing review and editing, Data curation, Methodology

M.TjonE.KivisakkP.et al

While the precise role of CD38 in MM cell biology remains incompletely understood, several investigations have explored its function as a glycoprotein and ectoenzyme in MM pathogenesis

Due to this, the production of melanin stops