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In addition, analysis of the synergistic effects of alcohol, obesity and smoking has shown that patients with this combination have a 7.4 times higher risk of developing HCC than do patients with only one of these risck factors (OR: 7.4, 95%: CI 2.1 to 14.6)
Because of that, any use in an aesthetic setting falls under the Human Medicines Regulations 2012 special needs exemption, which allows a prescriber to supply an unlicensed medicine only where there is a genuine, individual clinical need that a licensed product cannot meet
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