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Studies that have used intra-putamen infusion of GDNF in an open-label format have observed improvements in motor UPDRS scores, as well as some indications of restoration of the nigrostriatal pathway, both pathologically and through imaging
It easily crosses the blood-brain barrier, allowing it to effectively influence various brain functions

The key is the intent and the dose

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Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation