glutathione peroxidase metal Impact of carbonylation on peroxidase-1 activity in human hyperglycemic endothelial cells The Selenoprotein Glutathione Peroxidase 4:

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However, some tumor cells can use glutathione peroxidase 4 (GPX4), a lipid repair enzyme, to decrease LPO accumulation by converting toxic LPO to non-toxic lipid alcohols in the presence of glutathione (GSH), thereby protecting themselves from ferroptosis [18, 19]

N-acetyl cysteine overdose induced acute toxicity and hepatic microvesicular steatosis by disrupting gsh and interfering lipid metabolisms in normal mice

Smith J, Ladi E, Mayer-Proschel M, Noble M

[DOI] [PMC free article] [PubMed] [Google Scholar] [63].Nisoli E, Clementi E, Carruba MO, Moncada S

reported that the deubiquitinase ovarian tumor protein 1 can directly interact and stabilize SLC7A11, thereby inhibiting ferroptosis [68]