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Because the whole mechanism depends on the copper being chelated not just floating in solution the COA needs to confirm both the peptide sequence AND the copper binding

& Marques, C

While injections of essential vitamins, like B12, and other nutrients help make up for what the body lacks, vitamin B12 supplementation is widespread, especially with vitamin deficiencies on the rise

Although promising in vitro , their clinical application remains limited, and further development is required to evaluate their therapeutic potential

Demyelination particularly affects bundles passing through basal ganglia and pontine fibres 75,76

doi:10.1038/s41422-020-0323-8