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Description
However, regardless of this is the isoform with the highest sensitivity to citrate in normal tissues 178 , phosphofructokinase-1 in tumors exhibits reduced sensitivity to citrate, accompanied by increased sensitivity to activation by fructose-1,-6-bisphosphate 179,180,181
It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models
doi: 10.3390/microorganisms9071486 410 SzntMDzsaAAntalDSzabKKemnyLBaiP
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Always consult your provider before starting.* Storage: Keep in a refrigerated or cool, dry place as instructed
pFBA is a variant of regular flux balance analysis
